The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target?

Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons. In return, the central nervous system provides feedback and modulates the afferent stream of information through efferent neurons. The medial olivocochlear efferent system makes direct synaptic contacts with outer hair cells and inhibits amplification brought about by the active mechanical process inherent to these cells. This feedback system offers the potential to improve the detection of signals in background noise, to selectively attend to particular signals, and to protect the periphery from damage caused by overly loud sounds. Acetylcholine released at the synapse between efferent terminals and outer hair cells activates a peculiar nicotinic cholinergic receptor subtype, the α9α10 receptor. At present no pharmacotherapeutic approaches have been designed that target this cholinergic receptor to treat pathologies of the auditory system. The potential use of α9α10 selective drugs in conditions such as noise-induced hearing loss, tinnitus and auditory processing disorders is discussed.Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; ArgentinaFil: Katz, Eleonora. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; ArgentinaFil: Fuchs, Paul A.. The Johns Hopkins University School of Medicine; Estados Unido

Quantification of efficiency improvements from integration of battery energy storage systems and renewable energy sources into domestic distribution networks

Due to the increasing use of renewable, non-controllable energy generation systems energy storage systems (ESS) are seen as a necessary part of future power delivery systems. ESS have gained research interest and practical implementation over the past decade and this is expected to continue into the future. This is due to the economic and operational benefits for both network operators and customers, battery energy storage system (BESS) is used as the main focus of this research paper. This paper presents an analytical study of the benefits of deploying distributed BESS in an electrical distribution network (DN). The work explores the optimum location of installing BESS and its impact on the DN performance and possible future investment. This study provides a comparison between bulk energy storage installed at three different locations; medium voltage (MV) side and low voltage (LV) side of the distribution transformer (DT) and distributed energy storage at customers’ feeders. The performance of a typical UK DN is examined under different penetration levels of wind energy generation units and BESS. The results show that the minimum storage size is obtained when BESS is installed next to the DT. However, the power loss is reduced to its minimum when BESS and wind energy are both distributed at load busbars. The study demonstrates that BESS installation has improved the loss of life factor of the distribution transformer

Libor at crossroads: stochastic switching detection using information theory quantifiers

This paper studies the 28 time series of Libor rates, classified in seven maturities and four currencies), during the last 14 years. The analysis was performed using a novel technique in financial economics: the Complexity-Entropy Causality Plane. This planar representation allows the discrimination of different stochastic and chaotic regimes. Using a temporal analysis based on moving windows, this paper unveals an abnormal movement of Libor time series arround the period of the 2007 financial crisis. This alteration in the stochastic dynamics of Libor is contemporary of what press called "Libor scandal", i.e. the manipulation of interest rates carried out by several prime banks. We argue that our methodology is suitable as a market watch mechanism, as it makes visible the temporal redution in informational efficiency of the market.Comment: 17 pages, 9 figures. arXiv admin note: text overlap with arXiv:1508.04748, arXiv:1509.0021

A permutation Information Theory tour through different interest rate maturities: the Libor case

This paper analyzes Libor interest rates for seven different maturities and referred to operations in British Pounds, Euro, Swiss Francs and Japanese Yen, during the period years 2001 to 2015. The analysis is performed by means of two quantifiers derived from Information Theory: the permutation Shannon entropy and the permutation Fisher information measure. An anomalous behavior in the Libor is detected in all currencies except Euro during the years 2006--2012. The stochastic switch is more severe in 1, 2 and 3 months maturities. Given the special mechanism of Libor setting, we conjecture that the behavior could have been produced by the manipulation that was uncovered by financial authorities. We argue that our methodology is pertinent as a market overseeing instrument.Comment: arXiv admin note: text overlap with arXiv:1304.039

Surrogate-Based Design Optimization of Multi-Band Antenna

In this work, design optimization process of a multi-band antenna via the use of artificial neural network (ANN) based surrogate model and meta-heuristic optimizers are studied. For this mean, first, by using Latin-Hyper cube sampling method, a data set based on 3D full wave electromagnetic (EM) simulator is generated to train an ANN-based model. By using the ANNbased surrogate model and a meta-heuristic optimizer invasive weed optimization (IWO), design optimization of a multi-band antenna for (1) 2.4-3.6 GHz for ISM, LTE, and 5G sub-frequencies, and (2) 9-10 GHz for X-band applications is aimed. The obtained results are compared with the measured and simulated results of 3D EM simulation tool. Results show that the proposed methodology provides a computationally efficient design optimization process for design optimization of multiband antennas. © 2022 Applied Computational Electromagnetics Society (ACES). All rights reserved

Design and realization of dual band stacked antenna via three-dimensional printing technology

With the ever-increasing demands for high-performancewireless communication systems, the need of fast andlow-cost realization of antenna stages had also becomemore crucial for wireless communication industry.Herein, design and low-cost realization of a three-dimensional (3D) printed dual band Stacked Micro-strip Patch Array (SMPA) antenna has been studied. A3D electromagnetic-based simulation model of the pro-posed SMPA antenna has been created in CST Micro-wave Studio. The antenna achieves a simulated gainlevel of almost 8.3 dBi at 5.2 and 10.4 GHz frequen-cies. Then, the antenna design with optimally selectedparameters has been prototyped via the use of 3Dprinting technology. The prototyped antenna has ameasured gain level of 7.2 dBi at the operation fre-quencies. Furthermore, the experimental results of theprototyped antenna have been compared with the sim-ulated results. From the compared results, it can beconcluded that not only the proposed antenna designhas achieved high-performance measures comparedwith counterpart designs in the literature but also it ispossible to achieve an accurate, fast, and low-cost real-ization via the use of 3D printing technolog

Transcriptional regulation os phenylalaline biosynthesis and utilization

Conifer trees divert large quantities of carbon into the biosynthesis of phenylpropanoids, particularly to generate lignin, an important constituent of wood. Since phenylalanine is the precursor for phenylpropanoid biosynthesis, the precise regulation of phenylalanine synthesis and utilization should occur simultaneously. This crucial pathway is finely regulated primarily at the transcriptional level. Transcriptome analyses indicate that the transcription factors (TFs) preferentially expressed during wood formation in plants belong to the MYB and NAC families. Craven-Bartle et al. (2013) have shown in conifers that Myb8 is a candidate regulator of key genes in phenylalanine biosynthesis involved in the supply of the phenylpropane carbon skeleton necessary for lignin biosynthesis. This TF is able to bind AC elements present in the promoter regions of these genes to activate transcription. Constitutive overexpression of Myb8 in white spruce increased secondary-wall thickening and led to ectopic lignin deposition (Bomal et al. 2008). In Arabidopsis, the transcriptional network controlling secondary cell wall involves NAC-domain regulators operating upstream Myb transcription factors. Functional orthologues of members of this network described have been identified in poplar and eucalyptus, but in conifers functional evidence had only been obtained for MYBs. We have identified in the P. pinaster genome 37 genes encoding NAC proteins, which 3 NAC proteins could be potential candidates to be involved in vascular development (Pascual et al. 2015). The understanding of the transcriptional regulatory network associated to phenylpropanoids and lignin biosynthesis in conifers is crucial for future applications in tree improvement and sustainable forest management. This work is supported by the projects BIO2012-33797, BIO2015-69285-R and BIO-474 References: Bomal C, et al. (2008) Involvement of Pinus taeda MYB1 and MYB8 in phenylpropanoid metabolism and secondary cell wall biogenesis: a comparative in planta analysis. J Exp Bot. 59: 3925-3939. Craven-Bartle B, et al. (2013) A Myb transcription factor regulates genes of the phenylalanine pathway in maritime pine. Plant J, 74: 755-766. Pascual MB, et al. (2015) The NAC transcription factor family in maritime pine (Pinus pinaster): molecular regulation of two genes involved in stress responses. BMC Plant Biol, 15: 254.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Experimental and analytical study of cracks under biaxial fatigue

Most mechanical components experience multi-axial cyclic loading conditions during service. Experimental analysis of fatigue cracks under such conditions is not easy and most works tend to focus more on the simpler but less realistic case of uni-axial loading. Consequently, there are many uncertainties related to the load sequence effect that are now well known and are not normally incorporated into the growth models. The current work presents a new methodology for evaluating overload effect in biaxial fatigue cracks. The methodology includes evaluation of mixed-mode (KI and KII) stress intensity factor and the Crack Opening Displacement for samples with and without overload cycle under biaxial loading. The methodology is tested under a range of crack lengths. All crack-tip information is obtained with a hybrid methodology that combines experimental full-field digital image correlation data and Williams' elastic model describing the crack-tip field.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech